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Email: rdd39@case.edu

 

Dixon  Dorand

Entering Class: 2010
PhD Program: Pathology/Immunology
Advisor: Alex Huang, MD, PhD

Undergraduate Institution: University of Alabama at Birmingham
Hometown: Montgomery, AL.

Research Interests: Cancer Biology/Immunology/CNS Immunology My project in the Huang lab focuses on the interactions between immune cells and tumors in the central nervous system. We use a syngeneic mouse medulloblastoma tumor model coupled with two photon microscopy to study immune interactions. Our ultimate goal is to develop directed immune therapies fight pediatric malignancies. Check out all of our projects at www.huanglab.com

About me: I joined the CWRU MSTP and moved to Cleveland after finishing a year of post-bac research at UAB. I rotated with Clark Distelhorst (Pathology) and Heather Broiher (Neuroscience) before eventually finding my place in the Huang lab. Outside of school my wife and I enjoy spending time with our two Bernese Mountain Dogs and hiking around the Cleveland Metroparks.

Comment about the MSTP program: The CWRU MSTP is a welcoming group that displays a great diversity of backgrounds and knowledge. I've appreciated all of the support from the program administrators and students as I've navigated through the first years of med school and now into my PhD. Their help was especially appreciated when it came time to apply for external funding from both the NIH and private organizations. And, of course, our summer retreat is always a great time to meet the incoming students.

Featured Publication:

Dorand RD, Nthale, J, Myers JT, Barkauskas DS, Avril S, Chirieleison SM, Pareek, TK, Abbott DW, Stearns DS, Letterio JJ, Huang AY, Petrosiute A. Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity. Science. 2016 Jul 22;353(6297):399-403. doi: 10.1126/science.aae0477. Epub 2016 Jul 21. PubMed PMID: 27463676

Additional Publications:

Shukla S^, Dorand RD^, Myers JT, Wood SE, Gulati NM, Stewart P, Commandeur U, Huang AY*, Steinmetz NF* Multiple administration of viral nanoparticles alter in vivo behavior - insights from intravital microscopy. ACS Biomaterials Science and Engineering 2016; 2(5): 829-837. (^co-first authors; *co-senior and co-corresponding authors)

Dorand RD, Barkauskas DS, Evans TA, Petrosiute A, Huang AY. Comparison of intravital thinned skull and cranial window approaches to study CNS immunobiology in the mouse cortex. Intravital. 2014 May;3(2). pii: e29728. PubMed PMID: 25568834; PubMed Central PMCID: PMC4283137

Barkauskas DS, Dixon Dorand R, Myers JT, Evans TA, Barkauskas KJ, Askew D, Purgert R, Huang AY. Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction. Exp Neurol. 2015 Apr;266:74-85. doi: 10.1016/j.expneurol.2015.02.018. Epub 2015 Feb 20. PubMed PMID: 25708987; PubMed Central PMCID: PMC4382434.

A heterogeneous mixture of F-series prostaglandins promotes sperm guidance in the Caenorhabditis elegans reproductive tract. Hoang HD, Prasain JK, Dorand D, Miller MA. PLoS Genet. 2013;9(1):e1003271. doi: 10.1371/journal.pgen.1003271. Epub 2013 Jan 31. PMID: 23382703

Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction. Edmonds JW, Prasain JK, Dorand D, Yang Y, Hoang HD, Vibbert J, Kubagawa HM, Miller MA. Dev Cell. 2010 Dec 14;19(6):858-71. doi: 10.1016/j.devcel.2010.11.005. PMID: 21145501

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