James  J  Ignatz-Hoover

Entering Class: 2010
PhD Program: Pathology/Cancer Biology
Advisor: David Wald, MD, PhD

Undergraduate Institution: University of Michigan
Hometown: Elyria, OH.

Research Interests: Cell mediated immunity, IBD, cancer immunology

About me: In my spare time I enjoy singing and swimming.

Comment about the MSTP program: A small and spirited community with people passionate about their field.

Featured Publication:

Ignatz-Hoover JJ, Wang H, Moreton SA, Chakrabarti A, Agarwal MK, Sun K, Gupta K, Wald DN. The role of TLR8 signaling in acute myeloid leukemia differentiation. Leukemia. 2014 Oct 6. doi: 10.1038/leu.2014.293. [Epub ahead of print] PubMed PMID: 25283842. PMCID: PMC4387126

Additional Publications:

Hu S, Ueda M, Stetson L, Ignatz-Hoover J, Moreton S, Chakrabarti A, Xia Z, Karan G, de Lima M, Agrawal MK, Wald DN. A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity. Mol Cancer Ther. 2016 Jul;15(7):1485-94. doi: 10.1158/1535-7163.MCT-15-0566. Epub 2016 May 9. PubMed PMID: 27196775; PubMed Central PMCID: PMC4936967.

Gupta K, Stefan T, Ignatz-Hoover J, Moreton S, Parizher G, Saunthararajah Y, Wald DN. GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation. Cancer Res. 2016 May 1;76(9):2743-53. doi: 10.1158/0008-5472.CAN-15-2290. Epub 2016 Mar 10. PubMed PMID: 26964622.

Funderburg N, Stubblefield Park S, Sung H, Hardy G, Clagett B, Ignatz-Hoover J, Harding CV, Fu, P, Katz J, Lederman M, Levine A. Circulating CD4(+) and CD8(+) T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation. Immunology. 2013 Sep;140(1):87-97. doi: 10.1111/imm.12114. PMCID: PMC3809709

Good PD, Kendall A, Ignatz-Hoover J, Miller EL, Pai DA, Rivera SR, Carrick B, Engelke DR. Silencing near tRNA genes is nucleosome-mediated and distinct from boundary element function. Gene. 2013 Aug 15;526(1):7-15. PMCID: PMC3745993

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