Pamela  F  Marcott

Entering Class: 2011
PhD Program: Physiology and Biophysics
Advisor: Christopher Ford, PhD

Undergraduate Institution: Wake Forest University
Hometown: Cincinnati, OH.

Research Interests: I am interested in studying the dynamics of dopamine release from axon terminals in the striatum and how it activates postsynaptic receptors. Dopamine transmission in this region has primarily been studied using electrochemical techniques, but by using a viral overexpression system we are able to gain insight into how postsynaptic D2-receptors on medium spiny neurons respond to the synaptic release of dopamine. Specifically, dopamine neurons release dopamine in both tonic and phasic patterns, so my research is investigating how postsynaptic D2-receptors differentially respond to tonic and phasic dopamine signals.

About me: I love to get out and do just about anything active (yoga, climbing, biking, running). Cleveland also has a great food and beer community that I enjoy taking advantage of as well!

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Featured Publication:

Marcott PF, Mamaligas AA, Ford CP. Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron. 2014 Oct 1;84(1):164-76. doi: 10.1016/j.neuron.2014.08.058. Epub 2014 Sep 18. PubMed PMID: 25242218. PMCID: PMCID4325987.

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