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Email: james.j.morrow@case.edu

 

James  J  Morrow

Entering Class: 2012
PhD Program: Pathology
Advisor: Peter Scacheri, PhD
Laboratory: BRB-647

Undergraduate Institution: The Pennsylvania State University
Hometown: Sarver, PA.

Research Interests: I am interested in understanding the process of cancer metastasis. Specifically, my project is focused on understanding how gene expression is dynamically regulated as tumor cells spread from their primary location to secondary metastatic sites.

About me: I grew up outside of Pittsburgh, PA. Outside of the lab I'm interested in running, biking, soccer, and other outdoor pursuits.

Comment about the MSTP program: I joined the MSTP following the completion of a year long research fellowship at the National Institutes of Health through the Howard Hughes Medical Institute Research Scholars Program. The MSTP has provided me an amazing opportunity to gain sound training as a researcher and to explore my own interests at this critical juncture of my education. The flexibility of the program and the opportunities afforded by it are unparalleled.

Featured Publication:

Morrow JJ, Mendoza A, Koyen A, Lizardo M, Ren L, Waybright TJ, Hansen RJ, Gustafson DL, Zhou M, Fan TM, Scacheri P, Khanna C. mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo. Clin Cancer Res. 2016 Jun 24. pii: clincanres.0326.2016. [Epub ahead of print] PubMed PMID: 27342399.

Additional Publications:

Morrow JJ, Mendoza A, Koyen A, Lizardo M, Ren L, Waybright TJ, Hansen RJ, Gustafson DL, Zhou M, Fan TM, Scacheri P, Khanna C. mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo. Clin Cancer Res. 2016 Jun 24. pii: clincanres.0326.2016. [Epub ahead of print] PubMed PMID: 27342399.

Morrow JJ, Khanna C. Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies. Crit Rev Oncog. 2015;20(3-4):173-97. Review. PubMed PMID: 26349415; PubMed Central PMCID: PMC4894524.

Ren L, Mendoza A, Zhu J, Briggs JW, Halsey C, Hong ES, Burkett SS, Morrow J, Lizardo MM, Osborne T, Li SQ, Luu HH, Meltzer P, Khanna C. Characterization of the metastatic phenotype of a panel of established osteosarcoma cells. Oncotarget. 2015 Oct 6;6(30):29469-81. doi: 10.18632/oncotarget.5177. PubMed PMID: 26320182; PubMed Central PMCID: PMC4745740.

Acquavella N, Clever D, Yu Z, Roelke-Parker M, Palmer DC, Xi L, Pflicke H, Ji Y, Gros A, Hanada K, Goldlust IS, Mehta GU, Klebanoff CA, Crompton JG, Sukumar M, Morrow JJ, Franco Z, Gattinoni L, Liu H, Wang E, Marincola F, Stroncek DF, Lee CC, Raffeld M, Bosenberg MW, Roychoudhuri R, Restifo NP. Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest. Cancer Immunol Res. 2015 Jan;3(1):37-47. doi: 10.1158/2326-6066.CIR-14-0122. Epub 2014 Oct 30. PubMed PMID: 25358764; PubMed Central PMCID: PMC4289107.

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