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Email: aes31@case.edu

 

Avery  E.  Sears

Entering Class: 2013
PhD Program: Pharmacology
Advisor: Krzysztof Palczewski, PhD
Laboratory: W-317

Undergraduate Institution: Case Western Reserve University
Hometown: Cleveland, OH.

Research Interests: My research investigates the mechanisms behind retinoid metabolism in the retina, specifically how the visual chromophore, 11-cis¬-retinol, is produced and transported.

About me:

Comment about the MSTP program:

Featured Publication:

Sears AE, Palczewski K. Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle. Biochemistry. 2016 Jun 7;55(22):3082-91. doi: 10.1021/acs.biochem.6b00319. PubMed PMID: 27183166. PMCID: PMC5555363.

Additional Publications:

Hofmann L, Gulati S, Sears A, Stewart PL, Palczewski K. An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device. Anal Biochem. 2016 Apr 15;499:63-5. doi: 10.1016/j.ab.2016.01.016. PubMed PMID: 26851339; PubMed Central PMCID: PMC4788517.

Golczak M, Sears AE, Kiser PD, Palczewski K. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nat Chem Biol. 2015 Jan;11(1):26-32. doi: 10.1038/nchembio.1687. Epub 2014 Nov 10. PubMed PMID: 25383759; PubMed Central PMCID: PMC4270908.

Golczak, M., Kiser, P.D., Sears, A.E., Palczewski, K. 2012. Structural basis for the acyltransferase activity of lecithin: retinol acyltransferase. Journal of Biological Chemistry. 287(28):23790-807.

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