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MSTP Mentor List (Sorted by Department) and Research Interest

Please click on a name to view a more detailed profile.

Eckhard Jankowsky
Biochemistry
Single molecule enzymology (RNA helicases) & single molecule studies of ribonucleoprotein machinery (HCV replication and pre-mRNA splicing)
Hung-Ying Kao
Biochemistry
Mechanisms of the transcriptional control by diverse signaling pathways; molecular basis of human diseases related to transcriptional regulation
Focco van den Akker
Biochemistry
Structural biology; infectious diseases/antibiotic resistance; cardiovascular diseases; small-molecule therapeutics design; cell signaling
Michael Weiss
Biochemistry
Structural mechanisms of human diseases; Transcriptional deregulation and protein misfolding with applications to diabetes and disorders of sexual development
A. Bolu Ajiboye
Biomedical Engineering
Development and control of brain-computer-interface (BCI) technologies for restoring function to individuals who have experienced severely debilitating injuries to the nervous system, such as spinal cord injury and stroke
Eben Alsberg
Biomedical Engineering
Tissue engineering and regenerative medicine; innovative biomaterials and bioactive factor delivery vehicles; control of stem cell fate decision; mechanotransduction and the influence of mechanics on cell behavior and tissue formation; therapeutic angiogenesis
Jeffrey Capadona
Biomedical Engineering
Our lab will be at the forefront of research into materials-based solutions to overcome the barriers to intimately integrated neural interfaces. We are interested in developing materials which will seamlessly assimilate within the neural tissue to facilitate molecular level connections with individual neurons by mediating the inflammatory response and interacting with the normal cellular machinery.
Dominique Durand
Biomedical Engineering
Neural engineering, neural prostheses, magnetic and electric stimulation of the nervous system, electrophysiology of epilepsy, computational neuroscience.
Agata A Exner
Biomedical Engineering
Minimally invasive methods of cancer treatment including: ultrasound-modulated, image-guided drug delivery, thermosensitizers for focused hyperthermia, and vasomodulation for improved local ablation and treatment follow-up
Robert Kirsch
Biomedical Engineering
Mechanics and control of human movement
Zheng-Rong Lu
Biomedical Engineering
Drug delivery and molecular imaging; novel targeted imaging agents for molecular imaging; novel MRI contrast agents; image-guided therapy and drug delivery; polymeric drug delivery systems; multi-functional delivery systems for nucleic acids
Anant Madabhushi
Biomedical Engineering
Quantitative image analysis; Multi-modal, multi-scale correlation of massive data sets for disease diagnostics, prognostics, theragnostics: cancer applications.
Cameron McIntyre
Biomedical Engineering
We hope to improve deep brain stimulation (DBS) for the treatment of movement disorders and provide the fundamental technology necessary for the effective application of DBS to new clinical arenas.
P. Hunter Peckham*
Biomedical Engineering
* Not currently accepting MSTP students for rotation or PhD placement
Andrew Rollins
Biomedical Engineering
His current research interests include the development and application of advanced optics and photonics technologies for imaging and characterization of biological samples, with particular emphasis on detection of early disease and monitoring of therapy in human tissues and investigating embryonic development. His primary research interest includes the technique of OCT.
Nicole Seiberlich
Biomedical Engineering
Advanced signal processing and data acquisition techniques for real-time MRI
Anirban Sen Gupta
Biomedical Engineering
Our principal research focus is on Drug Delivery and Nanomedicine. It encompasses mechanistic understanding of biological and pathological phenomena at the cellular, sub-cellular and biomolecular levels, and utilizing this knowledge to create bioinspired therapeutic and diagnostic technologies to interrogate, support, or treat the various phenomena.
Samuel Senyo
Biomedical Engineering
The Senyo group is interested in fundamental mechanisms regulating the differential regenerative response to heart damage observed across species, across ages, and in distinct forms of injury. Dr. Senyo performs comparative studies using mammalian model systems, including human stem cells.
Nicole Steinmetz
Biomedical Engineering
Design, development, and testing of novel nanoscale materials based on plant viral nanoparticles (VNPs) from plants for applications in medicine and materials science
Horst von Recum
Biomedical Engineering
The research in our laboratory focuses on novel platforms for the delivery of molecules and cells.
David Wilson
Biomedical Engineering
Biomedical image processing; digital processing and quantitative image quality of X-ray fluoroscopy images; interventional MRI.
Xin Yu*
Biomedical Engineering
* Not currently accepting MSTP students for rotation or PhD placement
Mukesh Jain
Cardiovascular Research Institute
Transcriptional mechanisms governing cellular differentiation and function
Satya Sahoo
Center for Clinical Investigation
Biomedical Big data, medical informatics with focus on data integration and scalable computing, data-driven approaches to understand role of brain connectivity in epilepsy seizure networks
James Spilsbury *
Center for Clinical Investigation
* Not currently accepting MSTP students for rotation or PhD placement
James Kazura
Center for Global Health & Diseases
Immunoregulatory mechanisms of pathogenesis; acquired resistance to infection; malaria
Christopher L King
Center for Global Health & Diseases
T cell differentiation, Malaria Schistosomiasis, Filariasis Neonatal immunity, IgE regulation Mechanisms of acquired immunity
Mark Chance
Center for Proteomics & Bioinformatics
Systems Biology, Protein Structure/Function, Cancer, Diabetes
Kristian Baker
Center for RNA Molecular Biology
Post-transcriptional regulation of gene expression; mRNA turnover; RNA quality control; non-coding RNA function
Jeffery Coller
Center for RNA Molecular Biology
Work in the Coller lab focuses on the destruction of messenger RNA (mRNA). mRNA decay ensures that previously transcribed messages do not translate indefinitely. The spectrum of decay rates is achieved via the interplay between three fundamental principles. First, mRNA decay is the default state; all messages will succumb. Second, RNA degradation is intimately connected to protein synthesis; a message that translates better is more stable and vice versa. Third, stabilization requires the mRNA be maintained in an ideal ribonucleoprotein context (mRNP); deviants are destroyed. The long term focus of my lab is to understand how these three principles interconnect and are regulated by the cell to forge the cellular mRNA landscape.
Donny Licatalosi
Center for RNA Molecular Biology
The major goal of my lab is to understand how different RBPs regulate gene expression during mouse spermatogenesis. Research in the lab will combine genetic, bioinformatic, biochemical, and high throughput methods to generate transcriptome-wide maps of RBP-RNA interactions and mRNA regulation in specific spermatogenic cell types (from stem cell to gamete).
Timothy Nilsen
Center for RNA Molecular Biology
RNA processing and transcription in nematodes. Homologous cell free systems are used to dissect in detail the mechanisms of cis- and trans-splicing as well as the transcription of UsnRNA genes
Blanton Tolbert
Chemistry
Understanding the molecular mechanisms RNA viruses use to express their genomes
Laura Nagy
Cleveland Clinic Pathobiology
Innate immune contributions to alcohol and non-alcoholic induced liver injury, mechanisms of hepatocyte cell death, adipose-gut-liver interactions in alcoholic liver disease, genetic contributions to ALD
Jay Alberts
Cleveland Clinic Biomedical Engineering, Concussion Center
How the brain controls skilled movements and how changes in brain function affect the movement performance; Parkinson's disease, stroke and concussion; improving movement and cognitive performance; concussion and mild dramatic brain injury
Nima Sharifi
Cleveland Clinic Cancer Biology
Metabolic and molecular mechanisms of resistance to hormonal therapy in advanced prostate cancer
Stanley Hazen
Cleveland Clinic Cellular and Molecular Medicine
Research description: inflammation biology, atherosclerosis, gut flora, asthma, HDL structure/function, internal medicine, preventive cardiology
Justin Lathia
Cleveland Clinic Cellular and Molecular Medicine
Our two main areas of interest involve using in vivo imaging models to interrogate the tumor microenvironment and examining communication mechanisms used by cancer stem cell to promote their maintenance. Currently our work is focused on malignant brain tumors but our technology and interests are applicable to many other tumor types.
Jonathan Smith
Cleveland Clinic Cellular and Molecular Medicine
We apply cell/molecular biology, biochemistry, and genetics/genomics to study three areas related to cardiovascular disease: atherosclerosis, reverse cholesterol transport, and atrial fibrillation.
Charis Eng
Cleveland Clinic Genomic Medicine Institute
Cancer genomic medicine translational research. Characterization of disease risks in inherited predisposition to cancer. Intracytoplasmic trafficking of PTEN and oxidative stress in cancer
Jacob Scott
Cleveland Clinic Hematology & Medical Oncology
"Nothing in biology makes sense except in the light of evolution” applies as much in the clinic as anywhere else. The difference is that our efforts to treat cancer and infectious diseases both speeds up, and direct evolution of the malady to higher fitness peaks than would be achieved in natural settings. Rather than focussing on individual mutation, we use a combination of mathematical models, experimental evolution and data science to study the process of the evolution of resistance itself.
Robert Fairchild
Cleveland Clinic Immunology
T-lymphocyte tolerance, transplantation immunology; T-cell mediated responses in the skin
Xiaoxia Li
Cleveland Clinic Immunology
Signal transduction in innate and adaptive immunity
Booki Min
Cleveland Clinic Immunology
T cell homeostasis, gd T cells, CD8 T cells, Role of basophils in adaptive immunity
Ganes Sen
Cleveland Clinic Molecular Genetics and Virology
Molecular Virology, Mechanism of Interferon Action, Recombinant DNA Technology, Genetic Regulation of Hypertension
Jennifer Yu
Cleveland Clinic Stem Cell Biology and Regenerative Medicine
Glioblastoma is the most common primary brain tumor and is fatal despite maximal therapy. Glioma stem cells (GSCs) are a subpopulation of cells that contribute to tumor progression. Our lab is focused on understanding mechanisms underlying key GSC tumorigenic properties with a long-term goal of uncovering potential therapeutic targets.
Mehmet Koyutürk
Computer Science and Engineering
Bioinformatics and Computational Biology, with emphasis on development of algorithms for data analysis in Systems Biology
Daniel Popkin
Dermatology
Our lab addresses fundamental questions in two related fields: viral pathogenesis and immunology. We apply this towards disease models (e.g. skin disease).
Jill Barnholtz-Sloan
General Medical Sciences (Oncology)
Cancer genetic/molecular epidemiology, biostatistics, bioinformatics, systems biology, brain tumors
Analisa DiFeo
General Medical Sciences (Oncology)
The overall goal of Dr. DiFeo's laboratory is to identify novel biomarkers of ovarian cancer therapeutic response and generate novel targeted molecular therapies that can work alone or in conjunction with current treatment options to combat ovarian cancer.
William Schiemann *
General Medical Sciences (Oncology)
* Not currently accepting MSTP students for rotation or PhD placement
Yan Li
Genetics & Genome Sciences
Functions of non-coding cis-regulatory elements (such as enhancers) in development and complex diseases, especially related to diabetic conditions
Ashleigh Schaffer
Genetics & Genome Sciences
Our laboratory is primarily interested in understanding the unique functions of ubiquitously expressed proteins in human brain development and pediatric neurological disease.
Drew Adams
Genetics and Genome Sciences
The Adams lab uses high-throughput screening and other chemical biology approaches to identify and optimize new drug candidates in neurodegenerative diseases, cancer, and other diseases.
Ann Harris
Genetics and Genome Sciences
Tissue-specific and temporal regulation of gene expression; analysis of cis-regulatory elements and the role of 3D chromatin structure and modifications in regulating transcription; functional genomics of epithelial cells with a focus on cystic fibrosls
Peter Harte
Genetics and Genome Sciences
Epigenetic regulation of chromatin structure and transcription, histone modifying enzymes, Polycomb silencing, genetic control of lifespan and aging
Thomas LaFramboise
Genetics and Genome Sciences
Developing and applying computational tools to identify molecular variants - both inherited and somatic - that contribute to cancer and related diseases in humans
Hua Lou
Genetics and Genome Sciences
Alternative RNA processing and its role in cancer development
Peter Scacheri
Genetics and Genome Sciences
Investigation of the epigenetic code in human health and disease
Paul Tesar
Genetics and Genome Sciences
Stem cell pluripotency and differentiation; developmental neurobiology; developmental genetics
Zhenghe John Wang
Genetics and Genome Sciences
Identifying novel genetic alterations, such as somatic mutations, gene amplifications and deletions, which alter critical gene functions involved in development of colon and gastric cancers
Anthony Wynshaw-Boris
Genetics and Genome Sciences
Research in Dr. Wynshaw-Boris's laboratory is focused on understanding genetic and biochemical pathways important for the development and function of the mammalian central nervous system, primarily using mouse models of human and mammalian diseases to define pathways disrupted in these diseases.
Randall Cebul
Medicine
Clinical epidemiology, medical decision making (health policy, clinical strategies, diagnostic technology assessment); screening, prevention, and primary care in populations; vascular disease, chronic illness, and common problems in primary care.
Isabelle Deschênes
Medicine
My research focuses on the molecular basis of cardiac arrhythmias. My work provides key insights into the fundamental basis of our understanding of the electrical function of the heart, which is critical for the much-needed design of novel cardiac therapies for cardiac arrhythmias. We study the fundamental molecules that underlie the electrical function of the heart, including the channel that is responsible for the initiation of the action potential, the cardiac sodium channel. We utilize molecular and electrophysiological techniques to study the structure-function of the sodium channel and have also applied insights from our fundamental studies to more translational research that is essential to understanding the role cardiac ion channels plays in inherited cardiac arrhythmias.
Goutham Narla *
Medicine
* Not currently accepting MSTP students for rotation or PhD placement
Andrei Maiseyeu
Medicine (Cardiovascular Medicine)
Our research team develops nanotechnology tools to better understand cardiometabolic diseases such as atherosclerosis, type 2 diabetes, and obesity. We engineer, make, and test new imaging probes, drug delivery vehicles, and sensors that help diagnose and treat these conditions.
Aaron Proweller
Medicine (Cardiovascular Medicine)
Molecular pathways regulating vascular development and morphogenesis including the role of Notch signaling in patterning, maturation and contractile function of the arterial vasculature
Diana Ramírez-Bergeron
Medicine (Cardiovascular Medicine)
Adaptive responses to changes in oxygen tension and the effect on blood cells and vessels; influence of hypoxic responses on the generation of cardiovascular stem/progenitor cells and their differentiation into various cardiovascular cell lineages; hypoxia and bone marrow stem cell niches
Kurt Stange
Medicine (Family Medicine & Community Health)
The generalist function, primary health care, practice-based research, community health, integrated quantitative & qualitative research methods, complex systems modeling, narrative inquiry
Fabio Cominelli
Medicine (Gastroenterology and Hepatology)
Crohn's Disease, General GI, Inflammatory Bowel Disease, Ulcerative Colitis.
Sanford Markowitz
Medicine (Hematology and Oncology)
Colon cancer genetics
Shigemi Matsuyama
Medicine (Hematology and Oncology)
Cancer Cell Biology, Cell Death Regulation, Cell Penetrating Peptide
Reshmi Parameswaran
Medicine (Hematology and Oncology)
I am a cancer biologist working on novel therapeutic approaches for cancer. Currently, I focus on ways to activate natural killer cells for adoptive therapy of pediatric cancers. I also focus in developing therapeutic tools combining immunology with glycobiology, exploiting the cancer cell specific immune receptors and glycan expression patterns.
Stanton Gerson
Medicine (Hematology-Oncology), Cancer Center
Transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells
Robert A Bonomo
Medicine (Infectious Diseases)
Structure function studies of beta-lactamases; understanding enzymological factors that permit the successful evolution of beta-lactamases in the clinic; development of immunological tools to study beta-lactamase expression in enteric bacilli; application of molecular diagnostics to the rapid diagnosis of infectious diseases; testing and development of novel beta-lactams and beta-lactamase inhibitors
W Henry Boom
Medicine (Infectious Diseases)
T cell biology, tuberculosis, immune evasion, pulmonary host defense, antigen processing, anti-microbial immunity, basic and translational TB research.
David Canaday
Medicine (Infectious Diseases)
My lab studies the immunology of infectious diseases. My federally funded project currently is the study of HIV-TB interaction with a specific focus on cellular interactions that result in loss of control of M. tuberculosis. The second focus of the lab is on understanding the immune defects that develop with aging.
Michael Lederman
Medicine (Infectious Diseases)
Mechanisms of immune deficiency and immune restoration in HIV infection
Carlos Subauste
Medicine (Infectious Diseases)
Immunology, cell signaling in host-pathogen interactions, Toxoplasma, HIV, autophagy, selective blockade of CD40 signaling to control disorders such as atherosclerosis and microvascular complications of diabetes
Jonathan Stamler
Medicine (Institute for Transformative Molecular Medicine)
Our focus is on molecular, cellular and physiological aspects of redox biology, in particular the functions of nitric oxide in cellular signaling, and the roles of dysregulated redox mechanisms in human disease.
Susan Brady-Kalnay
Molecular Biology and Microbiology
* Not currently accepting MSTP students for rotation or PhD placement
Jonathan Karn
Molecular Biology and Microbiology
Control of Gene Expression in HIV
Alan Levine
Molecular Biology and Microbiology
Immune regulation in the mucosa: Role of the mucosal T lymphocyte and epithelial cell in intestine
Liem Nguyen
Molecular Biology and Microbiology
Host-mycobacterial interactions; virulence factors of Mycobacterium tuberculosis; antibiotic resistance and cell biology of mycobacteria
Arne Rietsch
Molecular Biology and Microbiology
Pseudomonas aeruginosa is a major cause of hospital-acquired infections, as well as the principal pathogen afflicting cystic fibrosis patients. We study the primary virulence factor of P. aeruginosa, its type III secretion system, which is a molecular syringe that the bacterium uses to inject proteins into host cells. We are interested in understanding how this nanomachine works, as well as in understanding how the injected effector proteins prevent clearance of the bacterium by the patient’s immune system.
Jacek Skowronski
Molecular Biology and Microbiology
Our recent efforts have been broadly aimed to identify cellular co-factors of HIV/SIV-encoded proteins, as well as of selected cellular proteins that can block HIV replication.
Eli Bar
Neurological Surgery
Identification and targeting of cancer cell intrinsic signaling nodes in Glioblastoma
Yu (Agnes) Luo
Neurological Surgery
The Luo Laboratory focuses on developing cell replacement therapy for neurodegenerative disease, including Parkinson’s disease (PD), stroke and traumatic brain injury.
Heather Broihier
Neurosciences
Developmental neurobiology; Molecular mechanisms of synaptic development and plasticity
Evan Deneris
Neurosciences
Molecular genetics of the brain serotonergic transmitter system
Polyxeni (Pola) Philippidou
Neurosciences
Molecular mechanisms of neural circuit assembly during development, genetic control of phrenic motor neuron identity; synaptic specificity in respiratory circuits; Hox genes
Jerry Silver
Neurosciences
Role of glial cells in development and regeneration of neural circuits, nerve regeneration, glia, axon guidance
Benjamin Strowbridge
Neurosciences
Synaptic Physiology, hippocampus, olfactory bulb, Computational Neuroscience
Richard Zigmond
Neurosciences
My laboratory studies plasticity in the adult nervous system. We are interested in the ways in which the chemistry of the adult nervous system can change and the functional consequences of such changes. We focus particularly on alterations that occur in response to (1) neural damage and (2) changes in the neural activity.
Danny Manor*
Nutrition
* Not currently accepting MSTP students for rotation or PhD placement
Paul Park
Ophthalmology & Visual Sciences
Mechanism of action of rhodopsin and other G protein-coupled receptors
Irina Pikuleva
Ophthalmology & Visual Sciences
Mechanistic studies of the link between disturbed retinal cholesterol homeostasis and vascular retinal abnormalities; pharmacologic stimulation of cholesterol turnover in the brain to enhance memory and cognition and treat early stages of Alzheimer's disease
Edward Greenfield*
Orthopedics
* Not currently accepting MSTP students for rotation or PhD placement
Ronald Triolo
Orthopedics, MetroHealth Medical Center
Rehabilitation engineering, neural control of motion, lower-extremity neuroprostheses, orthopaedic biomechanics and prosthetic/orthotic design
Brian McDermott
Otolaryngology
Sensory Neurobiology, Hearing and Deafness, Zebrafish Genetics, Mechanotransduction, Synapse development, Translational Neuroscience
Qing Zheng
Otolaryngology
Genes, molecular pathways and drug discovery involved in disease processes in mouse models of human deafness, including Otitis Media (OM) and Usher syndrome
Derek Abbott
Pathology
Inflammatory diseases and innate immune signaling pathways
Stanley Adoro
Pathology
Hematopoiesis, hematopoietic stem cells, acute myeloid leukemia, T-cell homeostasis and autoimmunity
Brian Cobb
Pathology
Antigen processing and presentation of carbohydrate antigens
Clifford Harding
Pathology
Immunology, major histocompatibility complex (MHC) molecules, antigen processing, function of antigen presenting cells and T cells, Toll-like receptors, vaccine adjuvants, Cell Biology, phagocytosis, endocytosis, subcellular fractionation, Infectious Disease, mycobacteria, tuberculosis
Mark Jackson
Pathology
The Jackson laboratory focuses on genetic events that contribute to breast hyperplasia.
Qingzhong Kong
Pathology
Prion diseases, functions of cellular prion protein in biology and diseases, muscle stem cells, and gene therapy
M. Edward Medof
Pathology
Vincent Monnier
Pathology
Molecular mechanisms of protein aging, oxidative stress, complications of diabetes and aging, cataractogenesis, microbial enzyme technology
Parameswaran Ramakrishnan
Pathology
Dr. Ramakrishnan's lab focuses on signal transduction in immunity, metabolism and cancer using cellular and molecular approaches and animal models with the aim of identifying fundamental mechanisms leading to development and evaluation of therapeutic targets.
Jiri Safar
Pathology
Neurodegenerative diseases caused by protein misfolding; molecular basis of prion diseases; role of small oligomers of misfolded proteins in pathogenesis; translational medicine.
Alan Tartakoff*
Pathology
* Not currently accepting MSTP students for rotation or PhD placement
David Wald
Pathology
Identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML)
Xinglong Wang
Pathology
My research interest is to understand the mechanism(s) underlying neuronal death in various major neurodegenerative diseases with a focus on Alzheimer’s disease, Frontotemporal dementia and Amyotrophic lateral sclerosisFrontotemporal dementia.
T. Sam Xiao
Pathology
The Xiao lab uses structural and biochemical approaches to study important immune receptors with the goal of understanding and modulating their functions for diagnostic and therapeutic applications.
Lan Zhou
Pathology
The research in my laboratory is devoted to understanding Notch-dependent regulation of hematopoietic stem cell proliferation, differentiation and niche location. Our other projects include studying leukemia microenvironment regulation, Notch signaling in solid tumor progression, and fucosylated glycans in hematopoiesis and cancer biology.
Xiongwei Zhu
Pathology
Neurodegenerative mechanisms underlying Alzheimer disease and other neurodegenerative diseases
Mitchell Drumm
Pediatrics
Understanding how variants in the genome influence the course of disease for CF patients and how the CF genome adapts to the disease
Thomas Gerken
Pediatrics
Protein structure and dynamics; NMR techniques; molecular modeling of glycoproteins and mucins
Alex Huang
Pediatrics
Tumor Immunology; Intravital two-photon laser scanning microscopy; T cell and chemokine receptor biology; Cellular trafficking, migration and interaction in inflammation, cancer and auto-immunity
John Letterio
Pediatrics
The major focus of our work is on the discovery of the critical roles of TGF-ß in hematopoietic and immune cell function.
Chris Dealwis
Pharmacology
Understanding the structural organization requirements by multiple protein assemblies to facilitate biological function
Maria Hatzoglou
Pharmacology
Arginine metabolism, gene regulation, viral receptors and gene therapy
Ruth Keri
Pharmacology
Hormonal control of mammary gland development and construction of transgenic mouse models of breast cancer; functional genomics of mammary gland development and cancer.
Jason Mears
Pharmacology
Molecular machinery associated with mitochondrial division in yeast and mammalian cells; understanding the relationship between mitochondrial dynamics and disease
Vera Moiseenkova-Bell
Pharmacology
Mechanism of TRPA1 channel ligand activation; TRP channels in heart disease
Marvin Nieman
Pharmacology
Anti-platelet therapeutic targets for managing cardiovascular disease
Krzysztof Palczewski
Pharmacology
Mapping the Visual Transduction System
Phoebe Stewart
Pharmacology
Applying cryo-EM structural methods to a variety of biological complexes including viruses, viral/host factor complexes involving adenovirus and papillomavirus, and protein-based and polymer based nanoparticles
Derek Taylor
Pharmacology
My laboratory studies the structure and molecular mechanisms of macromolecular machines involved in DNA maintenance and RNA maturation and biogenesis.
Walter Boron
Physiology & Biophysics
Regulation of intracellular pH, gas channels
Matthias Buck
Physiology & Biophysics
Molecular Biophysics of small GTPase-protein interactions in neuronal, cardivascular, and cancer cell signaling. We use molecular biology, NMR and X-ray spectroscopy as well as thermodynamic measurements to determine the basic mechanisms by which proteins transmit signals in cells. In cells. Principal project: The plexin transmembrane receptor in axon guidance.
Sudha Chakrapani
Physiology & Biophysics
Understanding the role of structure and dynamics in the functioning of ion channels
George Dubyak
Physiology & Biophysics
Inflammatory and apoptotic signal transduction; Signaling by receptors for extracellular ATP in innate immunity, cardiovascular disease, and cancer
Joseph LaManna*
Physiology & Biophysics
* Not currently accepting MSTP students for rotation or PhD placement
Xin Qi
Physiology & Biophysics
Mitochondrial dysfunction in disease
Corey Smith
Physiology & Biophysics
Regulation of the sympatho-adrenal stress response
Julian Stelzer
Physiology & Biophysics
Cellular and molecular mechanisms of cardiac muscle contraction in health and disease
Witold Surewicz
Physiology & Biophysics
Molecular basis of prion diseases and other disorders of protein misfolding
William Bush
Population and Quantitative Health Sciences
Genomics research on Alzheimer’s disease
Dana Crawford
Population and Quantitative Health Sciences
Applying genetic variation data to large-scale epidemiologic and clinical cohorts to better understand human genotype-phenotype associations, with an emphasis on diverse populations
Darcy Freedman
Population and Quantitative Health Sciences
Implementation and dissemination of community-level public health interventions; Community-engaged applied public health research; Primary prevention of chronic disease; Nutrition, food security and obesity
Jonathan Haines
Population and Quantitative Health Sciences
Genomic and computational approaches to understand the pathophysiology of human disease
Sudha Iyengar
Population and Quantitative Health Sciences
Genetics of complex diseases in humans (ocular genetics/epidemiology, renal genetics, speech sound disorder/epidemiology, genetic methods)
Chun Li
Population and Quantitative Health Sciences
Statistical genetics; genetic epidemiology; ordinal data analysis.
Nora Nock
Population and Quantitative Health Sciences
Using various "-omics" and neuroimaging approaches to better understand the genetic, environmental, behavioral and neural determinants of obesity and cancer; innovative lifestyle interventions in overweight and obese cancer survivors
Fredrick Schumacher
Population and Quantitative Health Sciences
Deciphering the inherited genetic architecture of complex traits, particularly cancers of the prostate, colon and breast. My research employs the use of quantitative and population sciences, particularly molecular and genetic epidemiology, to elucidate the genetic architecture of complex phenotypes.
Catherine Stein
Population and Quantitative Health Sciences
Genetic and environmental susceptibility to tuberculosis and other infectious diseases, and multivariate methods for analyzing complex diseases
Daniel Tisch
Population and Quantitative Health Sciences
Epidemiology of lymphatic filariasis, malaria, and schistosomiasis. Meta-analysis and mathematical modeling of parasite control strategies. Evaluation of integrated parasite control programs.
Scott Williams
Population and Quantitative Health Sciences
Dr. Williams’ research focuses on studies of the distribution of genetic variation among human populations and the role that differences in patterns of variation play in disparity of disease among populations. He is especially interested in common, complex diseases that do not have genes of major effect, but are more likely to be due to genetic models involving interactions among risk factors. These interests have led to research dealing with diversity among African and African descent populations and studies of multiple diseases that are either more common in these populations, such as hypertension and preterm birth, or less common, such as gastric cancer.
Xiaofeng Zhu
Population and Quantitative Health Sciences
Genetic mapping studies of hypertension, obesity; development of statistical methods for association studies avoiding the effect of population stratification; admixture mapping; bioinformatics
Christopher Flask
Radiology
Quantitative MRI Assessments of Cystic Fibrosis, Diabetic Nephropathy, Sickle Cell Disease, Pyelonephritis, Polycystic Kidney Disease, and Non-Alcoholic fatty Liver Disease
Bingcheng Wang
Rammelkamp Center for Research, MetroHealth Hospital
Molecular mechanisms governing cell migration and proliferation, experimental therapy of cancer metastasis using tumor-targeting peptides.