MSTP Mentor List (Alphabetically) and Research Interests

Please click on a name to view a more detailed profile.

Derek Abbott
Inflammatory diseases and innate immune signaling pathways
Drew Adams
The Adams lab works at the interface of chemistry and biology, first using synthesis and high-throughput screening to identify new bioactive drug-like molecules, and then using biological techniques to characterize the cellular mechanisms of leading hits.
A. Bolu Ajiboye
Development and control of brain-computer-interface (BCI) technologies for restoring function to individuals who have experienced severely debilitating injuries to the nervous system, such as spinal cord injury and stroke
Jay Alberts
How the brain controls skilled movements and how changes in brain function affect the movement performance; Parkinson's disease, stroke and concussion; improving movement and cognitive performance; concussion and mild dramatic brain injury
Eben Alsberg
Tissue engineering and regenerative medicine; innovative biomaterials and bioactive factor delivery vehicles; control of stem cell fate decision; mechanotransduction and the influence of mechanics on cell behavior and tissue formation; therapeutic angiogenesis
Kristian Baker
Post-transcriptional regulation of gene expression; mRNA turnover; RNA quality control; non-coding RNA function
Jill Barnholtz-Sloan
Cancer genetic/molecular epidemiology, biostatistics, bioinformatics, systems biology, brain tumors
Robert A Bonomo
Structure function studies of beta-lactamases; understanding enzymological factors that permit the successful evolution of beta-lactamases in the clinic; development of immunological tools to study beta-lactamase expression in enteric bacilli; application of molecular diagnostics to the rapid diagnosis of infectious diseases; testing and development of novel beta-lactams and beta-lactamase inhibitors
W Henry Boom
T cell biology, tuberculosis, immune evasion, pulmonary host defense, antigen processing, anti-microbial immunity, basic and translational TB research.
Walter Boron
Regulation of intracellular pH, gas channels
Susan Brady-Kalnay
* Not currently accepting MSTP students for rotation or PhD placement
Heather Broihier
Developmental neurobiology; Molecular mechanisms of synaptic development and plasticity
Matthias Buck
Molecular Biophysics of small GTPase-protein interactions in neuronal, cardivascular, and cancer cell signaling. We use molecular biology, NMR and X-ray spectroscopy as well as thermodynamic measurements to determine the basic mechanisms by which proteins transmit signals in cells. In cells. Principal project: The plexin transmembrane receptor in axon guidance.
David Canaday
My lab studies the immunology of infectious diseases. My federally funded project currently is the study of HIV-TB interaction with a specific focus on cellular interactions that result in loss of control of M. tuberculosis. The second focus of the lab is on understanding the immune defects that develop with aging.
Jeffrey Capadona
Our lab will be at the forefront of research into materials-based solutions to overcome the barriers to intimately integrated neural interfaces. We are interested in developing materials which will seamlessly assimilate within the neural tissue to facilitate molecular level connections with individual neurons by mediating the inflammatory response and interacting with the normal cellular machinery.
Randall Cebul
Clinical epidemiology, medical decision making (health policy, clinical strategies, diagnostic technology assessment); screening, prevention, and primary care in populations; vascular disease, chronic illness, and common problems in primary care.
Sudha Chakrapani
Understanding the role of structure and dynamics in the functioning of ion channels
Mark Chance
Systems Biology, Protein Structure/Function, Cancer, Diabetes
Brian Cobb
Antigen processing and presentation of carbohydrate antigens
Jeffery Coller
Work in the Coller lab focuses on the destruction of messenger RNA (mRNA). mRNA decay ensures that previously transcribed messages do not translate indefinitely. The spectrum of decay rates is achieved via the interplay between three fundamental principles. First, mRNA decay is the default state; all messages will succumb. Second, RNA degradation is intimately connected to protein synthesis; a message that translates better is more stable and vice versa. Third, stabilization requires the mRNA be maintained in an ideal ribonucleoprotein context (mRNP); deviants are destroyed. The long term focus of my lab is to understand how these three principles interconnect and are regulated by the cell to forge the cellular mRNA landscape.
Fabio Cominelli
Crohn's Disease, General GI, Inflammatory Bowel Disease, Ulcerative Colitis.
Dana Crawford
Applying genetic variation data to large-scale epidemiologic and clinical cohorts to better understand human genotype-phenotype associations, with an emphasis on diverse populations
Chris Dealwis
Understanding the structural organization requirements by multiple protein assemblies to facilitate biological function
Evan Deneris
Molecular genetics of the brain serotonergic transmitter system
Isabelle Deschênes
My research focuses on the molecular basis of cardiac arrhythmias. My work provides key insights into the fundamental basis of our understanding of the electrical function of the heart, which is critical for the much-needed design of novel cardiac therapies for cardiac arrhythmias. We study the fundamental molecules that underlie the electrical function of the heart, including the channel that is responsible for the initiation of the action potential, the cardiac sodium channel. We utilize molecular and electrophysiological techniques to study the structure-function of the sodium channel and have also applied insights from our fundamental studies to more translational research that is essential to understanding the role cardiac ion channels plays in inherited cardiac arrhythmias.
Analisa DiFeo
The overall goal of Dr. DiFeo's laboratory is to identify novel biomarkers of ovarian cancer therapeutic response and generate novel targeted molecular therapies that can work alone or in conjunction with current treatment options to combat ovarian cancer.
Mitchell Drumm
Understanding how variants in the genome influence the course of disease for CF patients and how the CF genome adapts to the disease
George Dubyak
Inflammatory and apoptotic signal transduction; Signaling by receptors for extracellular ATP in innate immunity, cardiovascular disease, and cancer
Dominique Durand
Neural engineering, neural prostheses, magnetic and electric stimulation of the nervous system, electrophysiology of epilepsy, computational neuroscience.
Charis Eng
Cancer genomic medicine translational research. Characterization of disease risks in inherited predisposition to cancer. Intracytoplasmic trafficking of PTEN and oxidative stress in cancer
Agata A Exner
Minimally invasive methods of cancer treatment including: ultrasound-modulated, image-guided drug delivery, thermosensitizers for focused hyperthermia, and vasomodulation for improved local ablation and treatment follow-up
Robert Fairchild
T-lymphocyte tolerance, transplantation immunology; T-cell mediated responses in the skin
Christopher Flask
Quantitative MRI Assessments of Cystic Fibrosis, Diabetic Nephropathy, Sickle Cell Disease, Pyelonephritis, Polycystic Kidney Disease, and Non-Alcoholic fatty Liver Disease
Christopher Ford
Regulation of synaptic transmission in the dopamine system of the VTA
Darcy Freedman
Implementation and dissemination of community-level public health interventions; Community-engaged applied public health research; Primary prevention of chronic disease; Nutrition, food security and obesity
Thomas Gerken
Protein structure and dynamics; NMR techniques; molecular modeling of glycoproteins and mucins
Stanton Gerson
Transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells
Edward Greenfield*
* Not currently accepting MSTP students for rotation or PhD placement
Jonathan Haines
Genomic and computational approaches to understand the pathophysiology of human disease
Clifford Harding
Immunology, major histocompatibility complex (MHC) molecules, antigen processing, function of antigen presenting cells and T cells, Toll-like receptors, vaccine adjuvants, Cell Biology, phagocytosis, endocytosis, subcellular fractionation, Infectious Disease, mycobacteria, tuberculosis
Ann Harris
Tissue-specific and temporal regulation of gene expression; analysis of cis-regulatory elements and the role of 3D chromatin structure and modifications in regulating transcription; functional genomics of epithelial cells with a focus on cystic fibrosls
Peter Harte
Epigenetic regulation of chromatin structure and transcription, histone modifying enzymes, Polycomb silencing, genetic control of lifespan and aging
Maria Hatzoglou
Arginine metabolism, gene regulation, viral receptors and gene therapy
Stanley Hazen
Research description: inflammation biology, atherosclerosis, gut flora, asthma, HDL structure/function, internal medicine, preventive cardiology
Alex Huang
Tumor Immunology; Intravital two-photon laser scanning microscopy; T cell and chemokine receptor biology; Cellular trafficking, migration and interaction in inflammation, cancer and auto-immunity
Sudha Iyengar
Genetics of complex diseases in humans (ocular genetics/epidemiology, renal genetics, speech sound disorder/epidemiology, genetic methods)
Mark Jackson
The Jackson laboratory focuses on genetic events that contribute to breast hyperplasia.
Mukesh Jain
Transcriptional mechanisms governing cellular differentiation and function
Eckhard Jankowsky
Single molecule enzymology (RNA helicases) & single molecule studies of ribonucleoprotein machinery (HCV replication and pre-mRNA splicing)
Hung-Ying Kao
Mechanisms of the transcriptional control by diverse signaling pathways; molecular basis of human diseases related to transcriptional regulation
Jonathan Karn
Control of Gene Expression in HIV
James Kazura
Immunoregulatory mechanisms of pathogenesis; acquired resistance to infection; malaria
Ruth Keri
Hormonal control of mammary gland development and construction of transgenic mouse models of breast cancer; functional genomics of mammary gland development and cancer.
Christopher L King
T cell differentiation, Malaria Schistosomiasis, Filariasis Neonatal immunity, IgE regulation Mechanisms of acquired immunity
Robert Kirsch
Mechanics and control of human movement
Qingzhong Kong
Prion diseases, functions of cellular prion protein in biology and diseases, muscle stem cells, and gene therapy
Mehmet Koyutürk
Bioinformatics and Computational Biology, with emphasis on development of algorithms for data analysis in Systems Biology
Thomas LaFramboise
Developing and applying computational tools to identify molecular variants - both inherited and somatic - that contribute to cancer and related diseases in humans
Joseph Lamanna*
* Not currently accepting MSTP students for rotation or PhD placement
Justin Lathia
Our two main areas of interest involve using in vivo imaging models to interrogate the tumor microenvironment and examining communication mechanisms used by cancer stem cell to promote their maintenance. Currently our work is focused on malignant brain tumors but our technology and interests are applicable to many other tumor types.
Michael Lederman
Mechanisms of immune deficiency and immune restoration in HIV infection
John Letterio
The major focus of our work is on the discovery of the critical roles of TGF-ß in hematopoietic and immune cell function.
Alan Levine
Immune regulation in the mucosa: Role of the mucosal T lymphocyte and epithelial cell in intestine
Xiaoxia Li
Signal transduction in innate and adaptive immunity
Chun Li
Statistical genetics; genetic epidemiology; ordinal data analysis.
Donny Licatalosi
The major goal of my lab is to understand how different RBPs regulate gene expression during mouse spermatogenesis. Research in the lab will combine genetic, bioinformatic, biochemical, and high throughput methods to generate transcriptome-wide maps of RBP-RNA interactions and mRNA regulation in specific spermatogenic cell types (from stem cell to gamete).
Hua Lou
Alternative RNA processing and its role in cancer development
Zheng-Rong Lu
Drug delivery and molecular imaging; novel targeted imaging agents for molecular imaging; novel MRI contrast agents; image-guided therapy and drug delivery; polymeric drug delivery systems; multi-functional delivery systems for nucleic acids
Yu (Agnes) Luo
The Luo Laboratory focuses on developing cell replacement therapy for neurodegenerative disease, including Parkinson’s disease (PD), stroke and traumatic brain injury.
Anant Madabhushi
Quantitative image analysis; Multi-modal, multi-scale correlation of massive data sets for disease diagnostics, prognostics, theragnostics: cancer applications.
Danny Manor*
* Not currently accepting MSTP students for rotation or PhD placement
Sanford Markowitz
Colon cancer genetics
Shigemi Matsuyama
Cancer Cell Biology, Cell Death Regulation, Cell Penetrating Peptide
Brian McDermott
Sensory Neurobiology, Hearing and Deafness, Zebrafish Genetics, Mechanotransduction, Synapse development, Translational Neuroscience
Cameron McIntyre
We hope to improve deep brain stimulation (DBS) for the treatment of movement disorders and provide the fundamental technology necessary for the effective application of DBS to new clinical arenas.
Jason Mears
Molecular machinery associated with mitochondrial division in yeast and mammalian cells; understanding the relationship between mitochondrial dynamics and disease
M. Edward Medof
Booki Min
T cell homeostasis, gd T cells, CD8 T cells, Role of basophils in adaptive immunity
Vera Moiseenkova-Bell
Mechanism of TRPA1 channel ligand activation; TRP channels in heart disease
Vincent Monnier
Molecular mechanisms of protein aging, oxidative stress, complications of diabetes and aging, cataractogenesis, microbial enzyme technology
Laura Nagy
Innate immune contributions to alcohol and non-alcoholic induced liver injury, mechanisms of hepatocyte cell death, adipose-gut-liver interactions in alcoholic liver disease, genetic contributions to ALD
Goutham Narla *
* Not currently accepting MSTP students for rotation or PhD placement
Liem Nguyen
Host-mycobacterial interactions; virulence factors of Mycobacterium tuberculosis; antibiotic resistance and cell biology of mycobacteria
Marvin Nieman
Anti-platelet therapeutic targets for managing cardiovascular disease
Timothy Nilsen
RNA processing and transcription in nematodes. Homologous cell free systems are used to dissect in detail the mechanisms of cis- and trans-splicing as well as the transcription of UsnRNA genes
Nora Nock
Using various "-omics" and neuroimaging approaches to better understand the genetic, environmental, behavioral and neural determinants of obesity and cancer; innovative lifestyle interventions in overweight and obese cancer survivors
Krzysztof Palczewski
Mapping the Visual Transduction System
Reshmi Parameswaran
I am a cancer biologist working on novel therapeutic approaches for cancer. Currently, I focus on ways to activate natural killer cells for adoptive therapy of pediatric cancers. I also focus in developing therapeutic tools combining immunology with glycobiology, exploiting the cancer cell specific immune receptors and glycan expression patterns.
Paul Park
Mechanism of action of rhodopsin and other G protein-coupled receptors
P. Hunter Peckham*
* Not currently accepting MSTP students for rotation or PhD placement
Polyxeni (Pola) Philippidou
Molecular mechanisms of neural circuit assembly during development, genetic control of phrenic motor neuron identity; synaptic specificity in respiratory circuits; Hox genes
Irina Pikuleva
Mechanistic studies of the link between disturbed retinal cholesterol homeostasis and vascular retinal abnormalities; pharmacologic stimulation of cholesterol turnover in the brain to enhance memory and cognition and treat early stages of Alzheimer's disease
Daniel Popkin
Our lab addresses fundamental questions in two related fields: viral pathogenesis and immunology. We apply this towards disease models (e.g. skin disease).
Aaron Proweller
Molecular pathways regulating vascular development and morphogenesis including the role of Notch signaling in patterning, maturation and contractile function of the arterial vasculature
Xin Qi
Mitochondrial dysfunction in disease
Parameswaran Ramakrishnan
Dr. Ramakrishnan's lab focuses on signal transduction in immunity, metabolism and cancer using cellular and molecular approaches and animal models with the aim of identifying fundamental mechanisms leading to development and evaluation of therapeutic targets.
Diana Ramírez-Bergeron
Adaptive responses to changes in oxygen tension and the effect on blood cells and vessels; influence of hypoxic responses on the generation of cardiovascular stem/progenitor cells and their differentiation into various cardiovascular cell lineages; hypoxia and bone marrow stem cell niches
Arne Rietsch
Pseudomonas aeruginosa is a major cause of hospital-acquired infections, as well as the principal pathogen afflicting cystic fibrosis patients. We study the primary virulence factor of P. aeruginosa, its type III secretion system, which is a molecular syringe that the bacterium uses to inject proteins into host cells. We are interested in understanding how this nanomachine works, as well as in understanding how the injected effector proteins prevent clearance of the bacterium by the patient’s immune system.
Andrew Rollins
His current research interests include the development and application of advanced optics and photonics technologies for imaging and characterization of biological samples, with particular emphasis on detection of early disease and monitoring of therapy in human tissues and investigating embryonic development. His primary research interest includes the technique of OCT.
Jiri Safar
Neurodegenerative diseases caused by protein misfolding; molecular basis of prion diseases; role of small oligomers of misfolded proteins in pathogenesis; translational medicine.
Satya Sahoo
Biomedical Big data, medical informatics with focus on data integration and scalable computing, data-driven approaches to understand role of brain connectivity in epilepsy seizure networks
Peter Scacheri
Investigation of the epigenetic code in human health and disease
Ashleigh Schaffer
Our laboratory is primarily interested in understanding the unique functions of ubiquitously expressed proteins in human brain development and pediatric neurological disease.
William Schiemann *
* Not currently accepting MSTP students for rotation or PhD placement
Fredrick Schumacher
Deciphering the inherited genetic architecture of complex traits, particularly cancers of the prostate, colon and breast. My research employs the use of quantitative and population sciences, particularly molecular and genetic epidemiology, to elucidate the genetic architecture of complex phenotypes.
Nicole Seiberlich
Advanced signal processing and data acquisition techniques for real-time MRI
Ganes Sen
Molecular Virology, Mechanism of Interferon Action, Recombinant DNA Technology, Genetic Regulation of Hypertension
Anirban Sen Gupta
Our principal research focus is on Drug Delivery and Nanomedicine. It encompasses mechanistic understanding of biological and pathological phenomena at the cellular, sub-cellular and biomolecular levels, and utilizing this knowledge to create bioinspired therapeutic and diagnostic technologies to interrogate, support, or treat the various phenomena.
Samuel Senyo
The Senyo group is interested in fundamental mechanisms regulating the differential regenerative response to heart damage observed across species, across ages, and in distinct forms of injury. Dr. Senyo performs comparative studies using mammalian model systems, including human stem cells.
Nima Sharifi
Metabolic and molecular mechanisms of resistance to hormonal therapy in advanced prostate cancer
Jerry Silver
Role of glial cells in development and regeneration of neural circuits, nerve regeneration, glia, axon guidance
Jacek Skowronski
Our recent efforts have been broadly aimed to identify cellular co-factors of HIV/SIV-encoded proteins, as well as of selected cellular proteins that can block HIV replication.
Jonathan Smith
We apply cell/molecular biology, biochemistry, and genetics/genomics to study three areas related to cardiovascular disease: atherosclerosis, reverse cholesterol transport, and atrial fibrillation.
Corey Smith
Regulation of the sympatho-adrenal stress response
James Spilsbury *
* Not currently accepting MSTP students for rotation or PhD placement
Jonathan Stamler
Our focus is on molecular, cellular and physiological aspects of redox biology, in particular the functions of nitric oxide in cellular signaling, and the roles of dysregulated redox mechanisms in human disease.
Kurt Stange
The generalist function, primary health care, practice-based research, community health, integrated quantitative & qualitative research methods, complex systems modeling, narrative inquiry
Catherine Stein
Genetic and environmental susceptibility to tuberculosis and other infectious diseases, and multivariate methods for analyzing complex diseases
Nicole Steinmetz
Design, development, and testing of novel nanoscale materials based on plant viral nanoparticles (VNPs) from plants for applications in medicine and materials science
Julian Stelzer
Cellular and molecular mechanisms of cardiac muscle contraction in health and disease
Phoebe Stewart
Applying cryo-EM structural methods to a variety of biological complexes including viruses, viral/host factor complexes involving adenovirus and papillomavirus, and protein-based and polymer based nanoparticles
Benjamin Strowbridge
Synaptic Physiology, hippocampus, olfactory bulb, Computational Neuroscience
Carlos Subauste
Immunology, cell signaling in host-pathogen interactions, Toxoplasma, HIV, autophagy, selective blockade of CD40 signaling to control disorders such as atherosclerosis and microvascular complications of diabetes
Witold Surewicz
Molecular basis of prion diseases and other disorders of protein misfolding
Alan Tartakoff*
* Not currently accepting MSTP students for rotation or PhD placement
Derek Taylor
My laboratory studies the structure and molecular mechanisms of macromolecular machines involved in DNA maintenance and RNA maturation and biogenesis.
Paul Tesar
Stem cell pluripotency and differentiation; developmental neurobiology; developmental genetics
Daniel Tisch
Epidemiology of lymphatic filariasis, malaria, and schistosomiasis. Meta-analysis and mathematical modeling of parasite control strategies. Evaluation of integrated parasite control programs.
Blanton Tolbert
Understanding the molecular mechanisms RNA viruses use to express their genomes
Ronald Triolo
Rehabilitation engineering, neural control of motion, lower-extremity neuroprostheses, orthopaedic biomechanics and prosthetic/orthotic design
Focco van den Akker
Structural biology; infectious diseases/antibiotic resistance; cardiovascular diseases; small-molecule therapeutics design; cell signaling
Horst von Recum
The research in our laboratory focuses on novel platforms for the delivery of molecules and cells.
David Wald
Identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML)
Zhenghe John Wang
Identifying novel genetic alterations, such as somatic mutations, gene amplifications and deletions, which alter critical gene functions involved in development of colon and gastric cancers
Xinglong Wang
My research interest is to understand the mechanism(s) underlying neuronal death in various major neurodegenerative diseases with a focus on Alzheimer’s disease, Frontotemporal dementia and Amyotrophic lateral sclerosisFrontotemporal dementia.
Bingcheng Wang
Molecular mechanisms governing cell migration and proliferation, experimental therapy of cancer metastasis using tumor-targeting peptides.
Michael Weiss
Structural mechanisms of human diseases; Transcriptional deregulation and protein misfolding with applications to diabetes and disorders of sexual development
Scott Williams
Dr. Williams’ research focuses on studies of the distribution of genetic variation among human populations and the role that differences in patterns of variation play in disparity of disease among populations. He is especially interested in common, complex diseases that do not have genes of major effect, but are more likely to be due to genetic models involving interactions among risk factors. These interests have led to research dealing with diversity among African and African descent populations and studies of multiple diseases that are either more common in these populations, such as hypertension and preterm birth, or less common, such as gastric cancer.
David Wilson
Biomedical image processing; digital processing and quantitative image quality of X-ray fluoroscopy images; interventional MRI.
Anthony Wynshaw-Boris
Research in Dr. Wynshaw-Boris's laboratory is focused on understanding genetic and biochemical pathways important for the development and function of the mammalian central nervous system, primarily using mouse models of human and mammalian diseases to define pathways disrupted in these diseases.
T. Sam Xiao
The Xiao lab uses structural and biochemical approaches to study important immune receptors with the goal of understanding and modulating their functions for diagnostic and therapeutic applications.
Jennifer Yu
Glioblastoma is the most common primary brain tumor and is fatal despite maximal therapy. Glioma stem cells (GSCs) are a subpopulation of cells that contribute to tumor progression. Our lab is focused on understanding mechanisms underlying key GSC tumorigenic properties with a long-term goal of uncovering potential therapeutic targets.
Xin Yu*
* Not currently accepting MSTP students for rotation or PhD placement
Qing Zheng
Genes, molecular pathways and drug discovery involved in disease processes in mouse models of human deafness, including Otitis Media (OM) and Usher syndrome
Lan Zhou
The research in my laboratory is devoted to understanding Notch-dependent regulation of hematopoietic stem cell proliferation, differentiation and niche location. Our other projects include studying leukemia microenvironment regulation, Notch signaling in solid tumor progression, and fucosylated glycans in hematopoiesis and cancer biology.
Xiaofeng Zhu
Genetic mapping studies of hypertension, obesity; development of statistical methods for association studies avoiding the effect of population stratification; admixture mapping; bioinformatics
Xiongwei Zhu
Neurodegenerative mechanisms underlying Alzheimer disease and other neurodegenerative diseases
Richard Zigmond
My laboratory studies plasticity in the adult nervous system. We are interested in the ways in which the chemistry of the adult nervous system can change and the functional consequences of such changes. We focus particularly on alterations that occur in response to (1) neural damage and (2) changes in the neural activity.