Department: Center for RNA Molecular Biology
PhD Program Affiliation: Biochemistry
Research Description: Work in the Coller lab focuses on the destruction of messenger RNA (mRNA). mRNA decay ensures that previously transcribed messages do not translate indefinitely. The spectrum of decay rates is achieved via the interplay between three fundamental principles. First, mRNA decay is the default state; all messages will succumb. Second, RNA degradation is intimately connected to protein synthesis; a message that translates better is more stable and vice versa. Third, stabilization requires the mRNA be maintained in an ideal ribonucleoprotein context (mRNP); deviants are destroyed. The long term focus of my lab is to understand how these three principles interconnect and are regulated by the cell to forge the cellular mRNA landscape.
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